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Specifically, nicotine and its primary metabolite cotinine are metabolized by the uridine 5-diphospho-glucuronosyltransferase (UGT) superfamily enzymes: specifically UGT2B10 for nicotine and cotinine, and UGT2B7, UGT2B15, and UGT2B17 are responsible for metabolizing androgens

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while some animal studies have found weight decreases with e-cigarette exposure, these results have not been confirmed in other models, and the overall effect on body weight in humans remains uncertain

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Over time, your brain starts to crave not just the chemical, but the timing