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doi: 10.1007/s13668-024-00550-y 133 WaeberBBrunnerH

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Since the promoter region of MITF contains the consensus CRE sequence, the expression of MITF can also be increased by -MSH stimulation in a cAMP-dependent manner (23)

doi:10.1136/bmjopen-2018-027925 Mehta ND, Haroon E, Xu X, Woolwine BJ, Li Z, Felger JC

These and other studies gave impetus to the clinical development of the inhibitors of DPP-4 for diabetes therapy, and in a pivotal proof-of concept study by Ahren and coworkers in 2004, vildagliptin, developed by researchers at Novartis, showed hemoglobin A1c improvements to target levels of 7% in a 1-year trial, whereas a significant rise was observed in the placebo group (103)