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1 2 The Journal of Rural Health

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Physical Symptoms Physical side effects often merge with withdrawal symptoms if drug use is reduced or stopped: Weight changes or noticeable weight loss Cognitive difficulties and confusion Anxiety or panic attacks Neglect of hygiene or personal appearance Enlarged or constricted pupils Insomnia or disrupted sleep Poor hand-eye coordination Digestive upset like nausea or vomiting Persistent fatigue Abdominal pain or cramping Diarrhea Tremors Psychological Symptoms Psychological signs of feening focus on how an individual thinks and acts: Compulsive or obsessive behaviors Overwhelming sense of lost control Abrupt mood swings Paranoia or unfounded suspicions Lack of motivation or energy Shortened attention span Irregular speech patterns, either too quick or too slow These clues often indicate a severe substance use disorder

Moulton EA, Elman I, Becerra LR, Goldstein RZ, Borsook D

Despite its effects on the lungs, this addiction causes its users to be enslaved to it long-term