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NSAIDs like ibuprofen work by blocking prostaglandins, natural compounds that protect the stomach's mucous layer

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This combination promotes increased growth hormone levels, leading to improved muscle mass, fat metabolism, and overall energy production

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Fibrosis remains the biggest challengeImprovements in fibrosis appear secondary to reducing metabolic and inflammatory injury - Combination approaches, including anti-fibrotic therapies, will likely be needed What This Means for Clinicians: - We are moving toward combination, mechanism-based therapy rather than single-drug approaches - Understanding the gutliver and adiposeliver axes is becoming central to treatment decisions - Patient selection will matter