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Moreover, chronic (4 months) exposure to hookah smoke in mice resulted in significant increases in alveolar destructive index and mean linear intercept contributing to the chronic obstructive pulmonary disease picture in these animals [119]

Toutefois, des ingrdients (propylne glycol, glycrol, certains additifs) peuvent, lors du chauffage, se transformer en composs cancrognes comme le formaldhyde, lactaldhyde et lacroline, et se retrouver dans la vapeur inhale, bien qu des concentrations beaucoup plus faibles que dans la fume de la cigarette traditionnelle

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