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Key findings Within six months of starting GLP-1 therapy, the rate of hypotensive events increased from 8.7% to 10.2% The increased risk remained significant at 12 months, with hypotensive events rising from 13.6% to 14.3% Adults age 65 and older accounted for 53% of hypotensive events despite representing 37% of the study population Patients with Type 2 diabetes made up 75% of those experiencing hypotensive episodes but only 63% of the overall cohort In secondary analyses, the scientists found that weight loss alone did not explain the increased risk, suggesting other mechanisms of action may be at play Below is a Q&A with study senior author Dr

It was really easy to get insurance approval because its so cheap, she explained

Phase 2 trials studied doses of 1 mg, 4 mg, 8 mg, and 12 mg administered once weekly by subcutaneous injection, but it remains unlicensed in the UK

Discard the pen 56 days after first use, even if medication remains

229 Unlike attenuating stress-induced cardiac remodeling, reversing existing cardiac fibrosis remains significantly more challenging