Semaglutide belongs to a class of medications known as GLP-1 receptor agonists, which influence hormones involved in appetite regulation and metabolic signaling
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According to the abstract, the tongue biopsies showed increased activity of genes associated with taste signaling transduction pathways, neural plasticity, and renewal of taste buds in the tongue. Finally, the brain scans demonstrated that, in response to tasting a sweet solution, there was increased activity in the angular gyrus of the parietal cortex
That is usually fine, but it sometimes means GI side effects ease while appetite suppression stays adequate
doi:10.1016/j.ijnurstu.2012.02.012