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They were originally developed for diabetes, but have become widely used for weight loss because they slow digestion, reduce hunger, and help control blood glucose levels

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In pancreatic cells, activation of these G proteincoupled receptors is primarily mediated through pathways involving cyclic adenosine monophosphate (cAMP), protein kinase A ( PKA ), and cAMP response elementbinding protein ( CREB ), thereby enhancing glucose-dependent insulin secretion and supporting -cell function