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Krzyzanowski and Lebowitz [17] showed that subjects who continued to smoke during the 11 to 13 years of follow-up ran a two or three times higher risk of developing respiratory symptoms such as dyspnea and attacks of breathlessness compared with lifetime non-smokers

By the 1950s, manufactured cigarettes represented 80 percent of per-person tobacco consumption (Giovino 2002)

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They are compliant reformulations, each with distinct characteristics, pricing, and flavour-delivery mechanisms