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Participants then selected a date within the next 7 days, but no earlier than the day after the third day of baseline BP measurements, on which to abruptly end their snus intake

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Even if this comparison is promising, this is a definite limitation that does not allow for a robust evidence of excellent in vivo prediction of EpiAirway tissues in humans which is still quite far from prediction in the sense of a quantitative estimate of health risks from long term daily e-cigarette use by humans