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For Nat Sherman (recently acquired by Altria), complying with its agreement with FDA while retaining brand identity meant making changes to the marketing of existing products and creating new ones

Some of the components of the endocannabinoid system, such as FAAH (fatty acid amide hydrolase enzyme), play an important role in the reinforcing and pleasurable effects of nicotine (5)

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Supporting this, recent data demonstrated that ECA induced an inflammatory reaction both in vitro, on epithelial cells [4, 8], and in vivo in mice and in smokers