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As a result, chaperone insufficiency synergises with proteasome inhibition and defective autophagy to promote the accumulation of toxic protein species and destabilise neuronal proteostasis

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As GLP-1-based therapies reshape diabetes and obesity care, ongoing post-marketing safety monitoring will be essential to ensure that benefits continue to outweigh risks across diverse patient groups. She added future research may continue evaluating long-term and rare [GI] outcomes, particularly as these agents are increasingly prescribed for weight management in individuals without diabetes. For more information: Wajd Alkabbani, PhD, can be reached at [email protected].