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Role: Site PI Project Number: R01NR018147-01 Name of PD/PI: Dagata, Amy PI *Source of Support: NIH (URI) *Title: Interpretation and Utility of Novel Composite Structural Endpoints of Cumulative Damage and Disease Activity in Knee Osteoarthritis This innovative project will use OAI data to demonstrate how much change in cumulative damage and disease activity composite metrics translates to clinically meaningful benefit (or worsening) from knee-specific and whole-person perspectives