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Figure 5: Country-level comparison of tobacco use in 2000 and 2022 Between 2000 and 2022, the prevalence of tobacco use has declined in most countries

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Conclusions In conclusion, we explored the accuracy of the 2017 nosology for the cEDS diagnosis in a cohort of patients from different ages and sexes with a defined molecular defect and tried to offer a full picture of the multisystemic involvement and some views on the natural history of this condition