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Targeting downstream signaling pathways to TLRs recapitulates the effect of TLR-knockout on the promotion of K-ras driven lung cancer by COPD-like airway inflammation To further dissect the cell type specific mechanism of tumor promotion by TLR activation in a COPD setting, we studied the signaling checkpoints shared among TLRs, specifically MyD88/NF-B signaling

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"We discussed cremation, and she said, 'Never, never, ever let anyone cremate me.' She had this terrible fear of fire." Heffner also said that as next of kin she would have requested an autopsy, but she was never officially notified of Duke's death, and by the time she learned of the cremation, it was too late

This corresponds roughly to the consumption of 1-2 packs of cigarettes