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Furthermore, selective CB2 activation reduces M1 macrophages in favor of M2 polarization [114] and increases efferocytosis of apoptotic cells [115]

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Compare that to the smoking of a single high-nicotine cigarette which increased the resting measurement of systolic blood pressure times heart rate by 36%, also increased the venous carboxyhemoglobin level, and decreased the exercise time until angina by 23%

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