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Several international experts pointed out that the review does not follow the rigorous methodologies of systematic reviews and that the criteria for selecting studies were not defined in advance

Some immediate, short-term side effects of nicotine may include: Feelings of relaxation or euphoria Increased blood pressure Increased heart rate Congestion Heartburn Some long-term effects nicotine can have on the body may include: Emphysema Lung and mouth cancer Stroke Diabetes Heart attack Macular degeneration Gum disease Premature aging Fertility issues Pregnancy complications including miscarriage, stillbirth, and premature delivery Sudden infant death syndrome (SIDS) in babies exposed to cigarette smoke Psychological problems induced by nicotine abuse may include: Restlessness Depression Anxiety Irritability Because nicotine is highly addictive, it is particularly dangerous for teens under 18, whose brains are still developing

The researchers also looked at the birth outcomes and found that babies born to women in the e-cigarette group were 65% less likely to be low birth weight compared to the babies born to women in the nicotine patches group

ScHoolboy Q's "There He Go" includes lyrics about chiefing, and similar references appear throughout rap from that era