Nicotine Effects: Central Nervous System Dizziness Lightheadedness Abnormal sleep disturbances Blood-flow risk Headache Nicotine Effects: Cardiovascular System Atherosclerosis Aortic enlargement and dissection Increased clotting Heart rate fluctuation Increased blood pressure Coronary artery disease Tachycardia Arrhythmias Nicotine Effects: Respiratory System Shortness of breath Chronic obstructive pulmonary disease Bronchospasm Cancer Nicotine Effects: Muscular System Spinal disc degeneration Joint pain Tremors Nicotine Effects: Gastrointestinal System Peptic ulcer Diarrhea Nausea Dry mouth Heartburn Dyspepsia Cancer Mentioned health effects can all be attributed to nicotine but are greatly exacerbated by other compounds usually found in tobacco products, such as tar, carbon monoxide, toluene, or any of the other 4,000 substances regularly found in cigarettes

But in the move to adulthood, there are certainly mistakes to be made for Malia, it turns out to be one that she may have picked up from her father, Barack Obama
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Benowitz, Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics, 2010