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Altogether, muscle loss during GLP1RAs therapy is multifactorial, involving reduced protein intake and negative energy balance, hormonal adaptations, impaired mTOR signaling and protein synthesis, increased proteolysis and potential mitochondrial adaptations, and age, frailty, and physical inactivity as modifiers (Fig

Among the 136 RA patients enrolled from July 2019 to December 2020, 25 taking lipid-lowering agents were excluded from the analysis due to the potential impact of these drugs on the lipidome profile