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F17.290 with clear product documentation (nicotine dependence, e-cigarette) is the defensible pattern

Along with the patch, which is most commonly used, nicotine-replacement products include gum, lozenges, inhalers, and nasal spray

Another study on human organotypic oral epithelial cultures showed that IQOS, compared to CS, yielded less cytotoxicity (significant after 48 h post-exposure), secretion of proinflammatory mediators, and gene expression perturbations related to apoptosis, necroptosis, senescence, xenobiotic metabolism, and oxidative stress 58

They also requested information from JUUL about product marketing and whether it is targeting youth

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