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The message is clear: weight loss itself is a meaningful therapeutic lever in obese PsA patients, complicating any attempt to attribute GLP-1RA benefits to drug-specific mechanisms

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TIZI-035/001WO 322161-2568 herein results in a decrease blood levels of BUN of at least about 10%, at least about 20%, at least about 30%, at least about 40%, at least about 50%, at least about 60%, at least about 70%, at least about 80% or at least about 90% compared to blood levels of BUN prior to treatment

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Exact duration varies by compound