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However, no significant changes in LH and FSH levels were observed (156)

Research has explored its role in cellular growth signaling, differentiation pathways, and IGF-1 receptor interaction mechanisms in laboratory models

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Similarly, a 2019 meta-analysis published in Obesity Reviews concluded that weight cycling increases the risk of cardiometabolic disease, systemic inflammation, insulin resistance, and psychological distressespecially among women (Eun-Jung Rhee, 2017)