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It reduces blood flow, depriving these tissues of oxygen and nutrients
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"I took it around to Freddie, who was not in a good state at that time, May told the BBC in 2017
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Methylation of DNA may do so either directly, through physical impediment of protein binding, or indirectly, through chromatin remodeling and its effect on DNA accessibility for proteins that regulate DNA transcription (Portela and Esteller, 2010)
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