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Although useful for elucidating potential structural alterations among smokers, measures of gray matter are limited in their ability to inform interpretation of functional relations or behavioral implications

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Cigarette manufacturers knew this too, yet issued no guidance against altering smoking patterns and continued to promote light cigarettes as less hazardous

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In patients with HBV infection, smoking further increased the HCC risk by 1.4-fold, and even more dramatically, in individuals with HCV infection, the risk of HCC was increased 2.9-fold if there was a history of cigarette smoking [102]