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Clinical monitoring recommendations include: Baseline blood pressure measurement before initiating Zepbound Regular blood pressure and heart rate monitoring during dose titration (every 4-8 weeks) Assessment for orthostatic hypotension, particularly in patients taking antihypertensive medications Consideration of antihypertensive dose adjustments as weight loss progresses Monitoring of renal function and electrolytes in patients on diuretics or with significant gastrointestinal side effects Evaluation for medication-related adverse effects that might influence blood pressure (dehydration) Patients taking antihypertensive medications should be counseled about potential hypotension risk and instructed to report symptoms such as dizziness, lightheadedness, or syncope

Similarly, in the PNA group, a marked difference in expression patterns was observed between PNA + Vehicle and PNA + GLP1/E conditions, with a noticeable reduction in protein expression in GLP1/E-treated mice (Fig

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