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This effect drives smokers to continuously seek their next dose of nicotine, which partly explains cravings

Immunology 124, 401411 (2008)

Because diagnosis of nicotine dependence can rely heavily on density of smoking (dependent smokers have on average 8.73 [95% CI 6.9610.50] more pack-years by age-38 than non-dependent smokers), and because we have demonstrated SmPEGS increase with cumulative tobacco consumption, we further tested whether these associations with FTND were accounted for by accelerated accumulation of tobacco between the two ages

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long terme, cela pourrait la rendre moins efficace