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After all, cigarettes are often known to be more mainstream than cigars

Alpha diversity and beta diversity were calculated using QIIME software (version 1.9.1) and analyzed using the Wilcox text in the agricolae package in R

Despite the suggestion that smoking has a direct adverse effect on skeletal remodeling and bone cells, the observation of impaired bone formation was during nicotine exposure in an animal model, rather than showing a direct causal association with using cigarette smoke, which contains complex chemical mixtures of more than nicotine alone