nrf2 glutathione synthesis Dynamic modeling of pathway activation in liver cells after toxicant exposure NRF2 plays a critical role – intracellular glutathione synthesis Control of

Glutathione Measurements Intracellular glutathione levels and markers of oxidative stress were taken in blood cells from treatment and control samples collected during weeks 0 (baseline) and week 12 (follow-up)

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With too much acetaminophen, glutathione becomes depleted and NAPQI accumulates, binds with proteins to form adducts, and leads to necrosis of hepatocytes (Figure 1)

10.1111/jcmm.15904 132 NiZ.TaoL.XiaohuiX.ZelinZ.JiangangL.ZhaoS.et al (2017)

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