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Additional Causes Genetic conditions like Klinefelter syndrome Blockage or damage in sperm transport tubes Past surgeries or injuries affecting the reproductive organs Environmental exposure to toxins, pesticides, and heavy metals Conclusion Lifestyle changes like quitting smoking, moderating alcohol, maintaining healthy weight, and managing stress can improve sperm health

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Since smoking is a powerful risk factor for AMD, we hypothesized that smoke induces epigenetic-mediated degenerative RPE heterogeneity