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CS also impairs AM phagocytic function against the opportunistic fungal pathogen Candida albicans in murine models after 15 min of CS exposure.58 AMs from smokers have been shown to have defective autophagy,59 a cellular function that removes unnecessary or dysfunctional cellular components and required to eliminate intracellular Mycobacterium tuberculosis .60 In addition, nicotine in CS extract has been shown to impair AM M