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These gut-brain peptides include peptide glucagon-like peptide-1 (GLP-1)
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SURMOUNT-1: Tirzepatide for Obesity The SURMOUNT-1 trial (NEJM, 2022) studied tirzepatide weight loss in 2,539 adults with obesity (without diabetes) over 72 weeks: STEP 1: Semaglutide for Obesity The STEP 1 trial (NEJM, 2021) studied semaglutide 2.4mg in 1,961 adults with obesity (without diabetes) over 68 weeks: Cross-Trial Summary Comparing across trials (with the caveat that indirect comparison has limitations): tirzepatide 15mg produced about 6 percentage points more weight loss than semaglutide 2.4mg over similar timeframes
Repeating this once a week can help slow down premature greying
That is cross-trial inference, and it cannot establish superiority: the near-identical headline figures are a coincidence of separate experiments, not the result of a race
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