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Neuropsychopharmacol 41 , 30803091 (2016)

GSTT1 contributes to three interconnected systems: detoxification of environmental and occupational toxins, protection of lung and vascular tissues, and longterm cancer and cardiometabolic risk

This single change eliminates sleep disruption in the majority of affected users

p62 competes with NRF2 for binding to KEAP1, and this interaction induces a dependent autophagic degradation of KEAP1 and subsequent NRF2 stabilization and activation in both MEFs and HEK293 cells [198]

Conversely, the hepatic findings were more consistent, with all doses triggering oxidative stress and promoting liver injury