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Seven additional studies evaluated the efficacy of CHANTIX in patients with cardiovascular disease, in patients with chronic obstructive pulmonary disease [see Clinical Studies ], in patients instructed to select their quit date within days 8 and 35 of treatment [see Clinical Studies ], patients with major depressive disorder [see Clinical Studies ], patients who had made a previous attempt to quit smoking with CHANTIX, and either did not succeed in quitting or relapsed after treatment [see Clinical Studies ], in patients without or with a history of psychiatric disorder enrolled in a postmarketing neuropsychiatric safety outcome trial [see WARNINGS AND PRECAUTIONS , Clinical Studies ], and in patients who were not able or willing to quit abruptly and were instructed to quit gradually [see Clinical studies ]

Factors That Affect Detection Windows Generally, it is expected that the drug will exit the blood within 1-3 days , while cotinine will be cleared within 1-10 days , varying from one individual to the other