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Dehydration adds to the tired feeling and often gets missed because thirst cues drop alongside hunger cues

Numerically fewer patients reported adverse events such as gynecomastia or agitation, though the differences failed to reach statistical significance, likely in part due to small sample size

Mood Regulation: Linked to serotonin production, influencing mood and warding off depression

doi: 10.1074/mcp.M400221-MCP200 216 WalshAJCookRSManningHCHicksDJLafontantAArteagaCLet al

We also used cell-permeable 2-OG (dimethyl 2-OG, DM-2OG), as a control for 2-OG accumulation driving 2-HG formation, as excess 2-OG has been previously shown to drive PHD inhibition via L-2-HG 22,24