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Indeed, Nrf2 activators such as sulforaphane and hydroxylated fullerene have restored GSH levels and shown antiepileptic and neuroprotective properties in numerous epilepsy models (Wang et al., 2014

Plasma protein-bound GSH also increased after GSH administration, with a time course similar to that observed for free plasma GSH

Treatment with nizatidine in combination with either vitamin E, thioctic acid or a combination of both resulted in a significant increase in erythrocytic GPx and SOD activities and a significant decrease in plasma MDA level