Carbon monoxide in the inhaled cigarette smoke increases the levels of carboxyhemoglobin, the proportion of which can exceed 7.5% in smokers, while the average level in non-smokers is 0.32% 13
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This paradox has been attributed to several mechanisms, including the lower body weight of smokers, selection bias, survival effects, more intensive clinical management of cardiovascular risk factors in smokers, and the vasodilatory properties of chronic carbon monoxide exposure [12]
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Association of pro-inflammatory cytokines, cortisol and depression in patients with chronic obstructive pulmonary disease