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Trends Food Sci Technol (2021) 112:41930
Tirzepatide is currently only available on the NHS in England and Wales via specialist weight management services, with a phased roll out to primary care settings in England including GPs
It works by mimicking the natural hormone GLP-1, which regulates appetite and digestion
The effects of GLP-1 RAs on obesity are not solely due to weight loss, but some pleiotropic effects like decreased inflammation, oxidative stress, and fibrosis also play a role in some of the complications
Therefore, it is plausible that the reduction of this genus, as observed here, is likely to reflect the improved protein utilization by the host due to the increased NR
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