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In addition to secreting TGF-, neutrophils can also produce matrix metalloproteinase-9 (MMP-9) and elastase 32-34 , which can negatively affect the airways, including airway narrowing due to airway remodeling, neutrophil elastase-mediated mucus hypersecretion, increased airway smooth muscle responsiveness, and a rapid decline in lung function 35-37

Altered resting state functional connectivity of anterior insula in young smokers

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