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But it increases risk through multiple converging pathways: Direct DNA damage Hormonal stimulation Oxidative injury Immune suppression Carcinogen synergy The classification as a Group 1 carcinogen by the International Agency for Research on Cancer is not based on speculation

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Thus, the committee considered whether analogous associations of relevant, non-cigarette tobacco product use and cigarette smoking initiation existed to interpret the causal effect of e-cigarettes on smoking

For instance, Liao et al., developed a system to optimize the weaning process from mechanical ventilation