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5.7 Resistin Resistin, named as a result of inducing insulin resistance, is a 12.5-kDa cysteine-rich peptide, produced by macrophages and peripheral monocytes

In December 2024, a phase IIa dose-ranging trial (NCT06717425 ) to investigate this drug began, and is due to end in December 2025 5

February 27, 2026

Like natural IGF-1, IGF-1 LR3 binds to the IGF-1 receptor (IGF-1R) , a tyrosine kinase receptor located on the cell surface

These findings suggest that a mechanism similar to that observed in mice [10] is at work in humans and that combining metformin with DPP-4 inhibitors appears to be a rational way of enhancing GLP-1 signalling in pancreatic beta cells