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Here are the groups that are more at risk

So, B12 injections can last for one month with slow release into the blood. In contrast, an IV (intravenous) infusion gives you the dose immediately so that you get the benefits immediately, and the effects are shorter lived

Hydroxocobalamin: This is the form the NHS typically uses

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Chandys hypothesis, that the rapid onset of the repairing processes induced by B12 shots might overwhelm the system and temporarily cause a worsening in symptoms, similar to the Jarisch-Herxheimer reaction in those treated for Lyme disease