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3.4 Evaluation of Semaglutide Exposures and Bioavailability Following Oral Administration in Subjects with T2D With or Without Upper GI Disease The re-estimated model based on data from the trial in 55 subjects with T2D with or without upper GI disease [21] included covariate factors for T2D and for upper GI disease

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Erectile Dysfunction Risk Increased ~4.5 Men taking semaglutide were far more likely to receive a new diagnosis of erectile dysfunction or a prescription for ED medications such as PDE-5 inhibitors

The decrease in MACE did not reach statistical significance for the group which gained weight, as so few of those on semaglutide (0.5%) gained weight so the sample size was small

doi: 10.1016/S0021-9258(19)38942-2 46 WeinstockPHBisgaierCLAalto-SetlKRadnerHRamakrishnanRLevak-FrankSet al