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Defects in PINK1/Parkin-mediated mitophagy activated platelet-derived growth factor receptor (PDGFR), an important mediator in fibrosis, which promoted FB proliferation and MFB activation, exacerbating fibrosis in IPF, a chronic progressive disease characterized by the fibrosis and hardening of lung tissue

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However, a 2018 study using rats found that e-cigarettes are just as bad for the lungs as smoking and that long-term exposure has the potential to cause significant lung damage