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Smoking increased expression of CD14 and reduced expression of CD71 in a monocyte/macrophage population from BAL.38 Absence of the transferrin receptor CD71 in AMs is characterised by reduced expression of mature markers, impaired phagocytosis and expression of profibrotic genes.39 In COPD, lung macrophages from smokers expressed lower levels of the high affinity-scavenger receptor CD163 and lower levels of the non-opsonic receptor CD36 compared with ex-smokers.40 CD163 and CD36 both have an important role in efferocytosis, which is the clearance of apoptotic cells.41 CD91 has a role in phagocytosis as part of the CD91-calrecticulin mannose receptor complex