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They have exhibited a wide variety of biological activities for thousands of years, including targeting mitochondrial dysfunction ( 2 Mitochondrial dysfunctions in kidney diseases 2.1 Mitochondrial homeostasis imbalance Mitochondrial quality control (MQC) is an elaborate mechanism to maintain homeostasis, ensuring the enough numbers of functional mitochondria (Figure 1)

Ford ES, Giles WH, Dietz WH

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In experimental heart transplantation, NDP-alpha-MSH, a synthetic analogue of alpha-melanocyte-stimulating hormone (-MSH), demonstrated protective activity by influencing various molecular pathways associated with heart function preservation