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FIGURE 1 Interestingly, nicotine uptake in an in vitro rat brain endothelial capillary cell line, TR-BBB13, showed hydrophilic cationic molecules such as 1-methyl-4-phenylpyridinium (MPP+), tetraethylammonium (TEA), and l-carnitine that are substrates of OCTs had no inhibitory effects (Tega et al., 2018)