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Smoking and Male Infertility: An Evidence-Based Review 1 , 2 Ashok Agarwal, 1 Sezgin Ozgur Gunes, 1 , 3 Amit Shetty, 1 and Stefan Simon du Plessis 1 , 4 Abstract Many studies have reported that the contents of cigarette smoke negatively affect sperm parameters, seminal plasma, and various other fertility factors