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Cigars are designed for a leisurely smoking experience where the focus is on the rich flavors and aromatic scent, rather than inhalation into the lungs

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Smoking increases the risk of microvascular complications of diabetes like retinopathy and nephropathy

Thus, while hyperpolarization takes place in both ionocyte-depleted KO cultures, the response to electrically mediated depolarization is dampened in PNEC-low POU2F3 KO cultures and exaggerated in PNEC-high FOXI1 KO cultures, revealing an important contribution of PNECs to airway epithelial ion transport function