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It is designed to detect the disease earlyoften before symptoms develop or in individuals without a history of lung cancer

Both models stratified by smoking exposure and age group, and both adjusted for the survey design variables (sampling weights, strata, and clusters) and categorical covariates for sex and race/ethnicity

Striking differences in the epidemiological, clinical and molecular characteristics of lung cancers arising in never smokers versus smokers have been identified, suggesting that they are separate entities

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