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Detailed dose equivalence explanation The lowest dose of tirzepatide (5 mg) produced similar HbA1c reductions and body weight changes compared to the highest approved dose of semaglutide for diabetes (2 mg) in the SURPASS-2 trial

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Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin

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In another recent publication (126), it was shown that pretreatment with the dual-GLP-1/GIP receptor agonist DA3-CH or liraglutide could decrease the levels of ERS damage proteins (CHOP, GRP78,) and pro-apoptotic factors (Bax, Caspase12) as well as increase anti-apoptotic factor (Bcl-2), and reduce neuronal death and neurological damage after stroke in diabetic rats